10 Noteworthy Aesthetic Clinics in Singapore Offering Non-Surgical Collagen-Stimulators

Liquid collagen stimulator treatments, also known as bio-remodeling injectables, utilize a soluble polymer that stimulates collagen production, enhances skin firmness and elasticity, and promotes gradual yet natural volume improvement.

These treatments, administered by doctors, offer an alternative to surgical facelifts with minimal discomfort and downtime.

Trinity Medical Aesthetics

Trinity Medical Aesthetics offers a non-surgical collagen-stimulating injectable that uses a fully liquid formulation of polycaprolactone (PCL), a biocompatible material known to promote long-term collagen production.

Details:

• Liquid PCL formulation spreads evenly for whole-face collagen activation

• Forms a 3D dermal matrix to stimulate natural collagen production

• Improves skin firmness, texture, elasticity, and reduces wrinkles gradually

• Recommended protocol: 3 sessions spaced 4 weeks apart, with optional maintenance

Location: 1 Marine Parade Central, Parkway Centre

Book here: Trinity Medical Aesthetics

MODE Medical Clinic

MODE Medical Clinic offers a Liquid PDO Facelift, an advanced collagen-stimulating injectable formulated with fully solubilized polycaprolactone (PCL). This treatment uses a liquid delivery system and is performed using a 5-point technique, ensuring even distribution across the entire face. It is designed to stimulate the skin’s natural collagen production for firmer, lifted, and more youthful-looking skin without the use of threads or surgery.

Details:

• Fully liquid PCL formulation spreads naturally and evenly across the face

• Stimulates collagen synthesis to lift sagging skin and smooth fine lines

• Improves overall skin texture, elasticity, and firmness

• Results typically visible in 1–2 weeks, with continued improvement over months

• Recommended: 3 sessions at monthly intervals, with optional maintenance every 3–6 months

• CE-certified technology used by doctors for safe, full-face rejuvenation

  
  

Best For: Individuals seeking natural, long-lasting facial rejuvenation with minimal downtime and a lifting effect.

Locations: Centrepoint, Harbourfront, JEM

Book here: MODE Medical Clinic

Edwin Lim Medical Aesthetic Clinic

Edwin Lim offers a Liquid PCL Collagen Stimulator, which is a transparent, fully dissolved formula promoting skin elasticity and firmness. Results are gradual and natural, with bio-compatible properties and high spreadability.

Details:

• Even distribution of liquid PCL across the face

• Stimulates collagen for firmer, more radiant skin

• Minimally invasive with few injection points

• Gentle, biodegradable treatment

  
  

Locations: Orchard and Changi

Book here: Edwin Lim Medical Aesthetic Clinic

The Artisan Clinic

The Artisan Clinic offers a Liquid PCL Collagen Biostimulator. Administered using a 10-point injection method, the treatment spreads evenly throughout the face to reduce fine lines, improve elasticity, and restore skin firmness.

Details:

• 10-point full-face collagen stimulation technique

• Even distribution with no microparticles

• Biodegradable formulation that integrates naturally with skin

• Gradual improvement in skin texture, tone, and elasticity

• Suitable for subtle lifting and wrinkle reduction

  
  

Best For: Individuals seeking a non-particulate, full-face collagen boost with long-lasting, natural-looking results.

Location: Wisma Atria

Book here: The Artisan Clinic

ICON Medical Aesthetics

ICON Medical Aesthetics offers a Liquid PCL Collagen Stimulator, a biostimulating injectable designed to address the root cause of aging by stimulating the body’s natural collagen production. Unlike traditional fillers that only restore volume, this treatment promotes long-lasting collagenesis to improve skin elasticity, reduce wrinkles, and lift sagging skin for a youthful, rejuvenated appearance.

Details:

• Liquid PCL collagen stimulator for full-face rejuvenation and collagen production

• Even and homogeneous distribution with no microparticles

• Typically administered via 10 injection points per session

• Achieve a lifting effect with gradual natural collagen replacement

  
  

Best For: Individuals seeking a natural, long-lasting lift with gradual skin firming and wrinkle reduction, especially those who want to stimulate their body’s collagen for comprehensive facial rejuvenation.

Locations: Wisma Atria, Century Square Book here: ICON Medical Aesthetics

IMAGO Aesthetic Clinic

IMAGO Aesthetic Clinic offers PCL collagen stimulator treatments that combine volumizing effects with long-term collagen production. The carrier gel is gradually absorbed and replaced by new collagen, providing lasting skin rejuvenation with minimal downtime.

Details:

• PCL collagen stimulator combines immediate volume restoration with ongoing collagen support

• The gel carrier is naturally absorbed and replaced by newly formed collagen

• Minimally invasive with a short recovery time

• Typical treatment duration: approximately 30 minutes

  
  

Best For: Individuals seeking both volume enhancement and natural collagen stimulation

Locations: AMK Hub, Centrepoint

Book here: IMAGO Aesthetic Clinic

V Aesthetics Clinic

V Aesthetics Clinic offers a Liquid PCL (Polycaprolactone) Collagen Stimulator, providing a non-surgical option for facial rejuvenation.

Details:

• 100% fully dissolved PCL, ensuring even facial distribution

• Promotes collagen and elastin production for skin lifting and firming

• Uses a 5-point injection technique per side of the face

• Ideal for improving skin elasticity, tone, and texture

  
  

Best For: Those looking for subtle, pan-facial rejuvenation without threads or particulate fillers

Location: 18 Locations across Singapore

Book here: V Aesthetics Clinic

Astute Medical Clinic

Astute Medical Clinic offers a cannula-based PCL collagen stimulator, using liquid instead of threads or particles. It promotes firmness, skin lifting, hydration, and smoother texture with fewer injection points and minimal downtime.

Details:

• Cannula administration for safer delivery

• PCL biodegrades naturally to stimulate collagen

• Promotes skin hydration and lifting

• Low downtime and added convenience

  
  

Best For: Those looking for natural skin rejuvenation without the risks of surgery

Location: Orchard

Book here: Astute Medical Clinic

NU.U Clinic

NU.U Clinic offers Liquid Polycaprolactone (PCL) Collagen Biostimulator treatment, a non-surgical solution designed to stimulate collagen production and restore facial structure. This treatment provides gradual, natural-looking rejuvenation, firming skin, lifting sagging areas, and improving texture over time.

Details:

• Biostimulatory treatment that promotes the body’s natural collagen regeneration

• Liquid PCL spreads evenly across the face for pan-facial improvement

• Enhances skin firmness, reduces fine lines, and lifts sagging contours

• Minimally invasive with minimal downtime

• Performed by a medical professional with personalized consultation

  
  

Best For: Individuals seeking non-surgical facial rejuvenation that improves skin quality and firmness through gradual collagen stimulation.

Location: Bishan

Book here: NU.U Clinic

CeleVenus Wellness & Aesthetic Clinic

CeleVenus Wellness & Aesthetic Clinic provides Liquid PCL Collagen Stimulator treatment using a mapped injection technique. This non-surgical treatment helps firm and lift the skin, improve texture, and reduce the appearance of fine lines.

Details:

• Uses fully solubilised, transparent PCL for even pan-facial distribution

• Promotes collagen-enhanced skin firmness and elasticity

• Biodegradable formula with low risk of lumps or nodules

• Minimally invasive with minimal downtime; mild swelling may occur

• Treatment session typically takes around 45–60 minutes

  
  

Best For: Individuals seeking gradual, natural skin tightening and rejuvenation without surgery or particulate fillers.

Location: Ngee Ann City, Orchard Road

Book here: CeleVenus Wellness & Aesthetic Clinic

TWP Thoughts

Liquid PCL Collagen Stimulators offer a minimally invasive option for restoring firmness, texture, and volume through natural collagen production.

When performed by doctors in clinical settings, they can be part of a personalized anti-aging plan with minimal downtime. As always, consulting with a certified doctor is important to determine suitability and long-term maintenance.