Ultracol: The Rise of Liquid PDO in SG

As aesthetic medicine continues to evolve in Singapore, there is a noticeable shift towards treatments that prioritise skin regeneration over instant correction. Among these, Ultracol has emerged as a versatile option— also known in SG as a PDO Collagen Skin Booster and a Liquid PDO Threadlift, depending on its formulation.

While the name “Ultracol” is often used broadly, it is important to distinguish between its two key variants: Ultracol 100 and Ultracol 200—each designed with different clinical objectives in mind.

What Is Ultracol?

Ultracol is an injectable collagen biostimulator made from polydioxanone (PDO), a biodegradable material long used in absorbable surgical sutures.

Unlike traditional threadlifts that rely on physical threads, Ultracol works by:

• Stimulating fibroblast activity

• Encouraging natural collagen production

• Improving dermal structure over time

The PDO is processed into fine particles and injected into the skin, where it gradually dissolves while triggering a regenerative response. This makes Ultracol part of a broader category of collagen-stimulating injectables that focus on long-term skin quality rather than immediate lifting.

Ultracol 100: The PDO Collagen Skin Booster

Ultracol 100 is commonly referred to as a PDO Collagen Skin Booster, and its role is centred on skin quality enhancement.

Key Characteristics:

• Finer PDO particles

• More superficial dermal placement

• Even distribution across the skin

What It Targets:

• Dull or dehydrated skin

• Fine lines and early signs of ageing

• Enlarged pores and uneven texture

Rather than altering facial structure, Ultracol 100 works subtly to:

• Improve skin smoothness and elasticity

• Enhance hydration and radiance

• Support overall skin rejuvenation

The PDO Collagen Skin Booster aligns with the growing demand for “glass skin” outcomes—healthy, luminous skin achieved through regeneration rather than coverage.

Ultracol 200: The Liquid PDO Threadlift

Ultracol 200, in contrast, is often described as a Liquid PDO Threadlift, reflecting its role in providing deeper structural support.

Key Characteristics:

• Larger or denser PDO particles

• Injected into deeper dermal or subdermal layers

• More targeted placement

What It Targets:

• Mild to moderate skin laxity

• Early sagging (e.g. cheeks, jawline)

• Areas with volume loss

While it does not physically lift the skin in the same way as traditional threadlifts, Ultracol 200:

• Creates a collagen-stimulating scaffold within deeper layers

• Provides subtle support and contour improvement over time

• Enhances firmness and definition gradually

This is why it is termed a “liquid threadlift”—it mimics the biostimulatory effects of PDO threads without the insertion of actual threads.

Key Differences between the 2 types of PDO treatments:

Feature	Ultracol 100	Ultracol 200
Also known as	PDO Collagen Skin Booster	Liquid PDO Threadlift
Particle Size	Finer	Larger / more concentrated
Injection Depth	Superficial dermis	Deeper dermis / subdermis
Primary Goal	Skin quality & hydration	Structural support & firmness
Best For	Texture, pores, glow	Laxity, contour, mild volume loss
Price Range in Singapore	SGD330	SGD588

A Complementary Approach

Rather than being competing treatments, Ultracol 100 and 200 are often viewed as complementary tools.

In clinical practice in Singapore, they may be used together to address different layers of ageing:

• Ultracol 100 for surface refinement

• Ultracol 200 for deeper support

This layered approach reflects a broader trend in aesthetic medicine—treating the skin holistically across multiple depths, rather than relying on a single modality.

Ultracol’s rising popularity in Singapore mirrors a wider shift towards preventive and regenerative aesthetics, where patients are increasingly seeking:

• Natural-looking results

• Minimal downtime

• Long-term skin health

As a minimally invasive treatment, it is generally well tolerated, with common side effects limited to temporary redness, swelling, or mild bruising.

However, outcomes depend heavily on:

• Proper patient selection

• Choice between type of treatment

• Practitioner technique and experience

TWP Thoughts

Ultracol represents more than just a new injectable—it reflects a philosophical shift in aesthetic medicine towards collagen regeneration instead of volumization.

With Ultracol 100 positioned as a PDO Collagen Skin Booster and Ultracol 200 as a Liquid PDO Threadlift, the treatment offers flexibility across the spectrum of skin ageing—from early prevention to subtle structural support. In an industry moving towards understated, regenerative results, Ultracol stands out for its ability to work with the skin, rather than simply altering it.